Astragalus Polysaccharides 3.0

A giant leap forward for botanical drug development

In 2010, Astragalus Polysaccharides Injection became the first plant-based medicine to gain regulatory approval in Taiwan. This pivotal moment in PhytoHealth's journey was the culmination of two decades of meticulous research. Our dedicated team successfully isolated the potent ingredients from the Astragalus plant using our advanced rAPS® Tech purification technology. This breakthrough reshaped the way Western medicine views Astragalus.

Historically, Traditional Chinese Medicine primarily utilized natural extracts that contained varying amounts of the key ingredients, making consistency and potency a challenge. However, our "Refined Astragalus Polysaccharide" stands out. Through advanced purification processes, we've elevated a traditional herbal remedy to a precise, high-quality injectable medicine familiar to Western healthcare. Thanks to these advancements, our plant-derived medicines are now offered in over 90% of medical centers across Taiwan.

Highlights

rAPS® Tech: Transforms beneficial polysaccharides into high-quality medicinal ingredients derived from plants.
Refined Astragalus Polysaccharide: A distinct advancement over traditional scientific Chinese medicine, ensuring enhanced effectiveness and consistency.
State-of-the-Art Facility: We're proud to house Asia's first PIC/S GMP-certified facility for plant-based pharmaceuticals. This cutting-edge center enables the creation of both injectable and oral formulations
Leading the Charge in Astragalus Research: Our commitment to excellence is evident with 9 patented innovations. For 20 years, we've been pioneering the industry's advancements.
01

Astragalus Polysaccharides 3.0: Advancing Botanical Medicine

Enhanced Activity | Elevated Purity | Optimized Absorption | Amplified Effects

Traditional methods of infusing Astragalus root slices often fall short of extracting all of the potent ingredients. Astragalus Polysaccharides 3.0, the latest advancement, not only optimizes the potential of Astragalus but has also been recognized as a licensed drug eligible for health insurance coverage.
Brewing and boiling Astragalus is insufficient for break down the root's tough cell walls, resulting in a suboptimal dissolution rate of its beneficial polysaccharides and reduced absorption. While certain commercial Astragalus extracts attempt to disrupt these walls, many lack advanced purification techniques. This absence of purification leads to a mixture of polysaccharide molecules, compromising both purity and content, thereby diminishing the potential benefits. Additionally, some manufacturing processes expose these vital components to excessive heat, potentially degrading their efficacy and failing to harness specific molecular weights beneficial for health.
Crucially a significant 90% of commercially available Astragalus root slices are from varieties with limited efficacy, rendering increased consumption ineffective.

In fact, brewing and cooking Astragalus slices at home often result in incomplete cell wall breakage and very low polysaccharide dissolution rates. Naturally, this leads to poor absorption! Even some Astragalus extracts or scientific traditional Chinese medicines undergo a cell wall breaking step, but lack advanced purification. The polysaccharide molecules are mixed with numerous components, leading to low purity and content, significantly diminishing their functionality. Furthermore, the process often involves excessively high temperatures, damaging active structures, and lacking precise techniques to obtain specific effective molecular weights.

Not to mention that 90% of the Astragalus slices available in the market are considered ineffective*, meaning consuming them, no matter how much, would be meaningless.




Hyper-evolution ❱
Astragalus Polysaccharides 3.0

黃耆多醣注射劑費用

Utilizing rAPS®Tech, our plant-based medicine undergoes stages like cell-wall disruption, extraction, and refinement to produce 'refined Astragalus Polysaccharides.' Meeting Western pharmaceutical standards, it's evolved into Astragalus Polysaccharides 3.0, highlighting advancements in:

• Species Varieties   • Cultivation Techniques  
• Absorption Efficiency

• Active Components  • Purity Levels  • Clinical Validation


• Species Varieties        • Cultivation Techniques

• Absorption Efficiency      • Active Components

• Purity Levels       • Clinical Validation



The refinement technology for injection allows for the precise acquisition of active molecules.

With persistent refinement and innovation, the refined Astragalus Polysaccharides have evolved beyond the scope of traditional herbal remedies and supplements, establishing themselves as the nation's pioneering botanical medicine injection. Progressively, each step refines and perfects this process.

When benchmarked against Astragalus slices, extracts, and concentrated traditional formulations, refined Astragalus Polysaccharides stand out uniquely. Their distinction is clear across multiple facets, including variety, composition, technological processes, and versatile applications.

Below, we will concisely enumerate 12 major significant differences


Species
• Ineffective species
• Pharmacopoeia species
• High-Efficiency strains





Composition
• Types and Proportions of      Monosaccharides
• α or β Linkage Types
• Molecular Weight of       Polysaccharides



Technology
• Decoction Brewing, Without  Cell Wall Breakage
• Extraction After Cell Wall  Breakage, Without Purification
• rAPS® patented technology
Applications
• Flavor enhancement
• Health preserving
• High Efficacy, Phase IV   clinical study





Each modification in our process is deliberate, with every change crucial for refining and pharmaceutical transformation. For two decades, PhytoHealth has been on this journey, advancing consistently and determinedly.

rAPS®Tech is not limited to plant-based injectable medicine. In 2020, the PhytoHealth team broadened its application to oral dosages, breaking past barriers that once restricted large molecular polysaccharides to injections.

It's this innovation that sets refined Astragalus polysaccharides apart, consistently drawing recognition from the medical sector, academia, and prominent media outlets.

02

rAPS® Technology: A Global Leader

A two-decade lead over international counterparts, holding patents across 10 nations.

Emerging from Asia's premier PIC/S GMP-certified plant-based pharmaceutical facility, the rAPS® Tech refining technology boasts global distinction. Its patented innovations span countries like the United States, Japan, the UK, France, Germany, China, Taiwan, South Korea, Singapore, and Malaysia.


The Botanical Medicine Manufacturing Process:

rAPS®Tech Refinement Technology

refined Astragalus PolySaccharides

植物新藥 製程 ❱

rAPS®Tech
全程精製技術

refined Astragalus PolySaccharides

Grasping the intricacies of plant-based pharmaceuticals begins with a deep dive into the rAPS®Tech refinement technology. Through 7 patented procedures and a crucial molecular sieving step, we meticulously isolate, refine, and purify specific molecular weight ranges of Astragalus polysaccharides. The resulting refined products not only meet but often exceed the quality and efficacy standards established by Western prescription drugs.

The 7 core processes of rAPS® refining technology include: biphasic separation, layered extraction, centrifugal filtration, spray drying, tangential flow filtration, ion chromatography, and concentration drying. Each vial of Astragalus polysaccharide injectable must undergo 68 production processes and 141 inspection checkpoints.

Currently, PhytoHealth's "Refined Astragalus Polysaccharide Research Center" is dedicated to broadening the applications of this botanical compound. We're pioneering methods to overcome previous restrictions where large-molecule Astragalus polysaccharides were solely absorbable via intravenous injection. By enhancing absorption in oral forms, we're ensuring a more user-friendly approach that aligns seamlessly with daily life requirements.


03

Continuous breakthroughs! High-absorption crystalline structure for oral intake.

Transformation and Application of Injection Technology in Food

PhytoHealth Research has innovated with patented "micro-particle structures" in crystalline form, addressing solubility and stability hurdles. These advancements allow us to move beyond the confines of injections for large molecular polysaccharides. Now, they're tailored for daily and sustained usage, ensuring a more consumption method.


Prescription Medicine


'Injectable' botanical medicine


PhytoHealth boasts Taiwan's premier PIC/S GMP-certified plant dedicated to botanical medicine. For two decades, our unwavering commitment to botanical medicine research has earned us the National Innovation Awards in both 2011 and 2017. With a coveted TFDA drug license under our belt, over 90% of Taiwan's medical centers trust and utilize our products.

Our rAPS® Tech excels in the meticulous extraction of potent polysaccharide molecules. It ensures precision in specific molecular weights, monomer compositions, linkage patterns, and three-dimensional structures. Having undergone stringent Phase IV clinical trials, it also holds the distinction of being eligible for National Health Insurance coverage.

Prescription Medicine

'Injectable' botanical medicine

PhytoHealth boasts Taiwan's premier PIC/S GMP-certified plant dedicated to botanical medicine. For two decades, our unwavering commitment to botanical medicine research has earned us the National Innovation Awards in both 2011 and 2017. With a coveted TFDA drug license under our belt, over 90% of Taiwan's medical centers trust and utilize our products.

Our rAPS® Tech excels in the meticulous extraction of potent polysaccharide molecules. It ensures precision in identifying specific molecular weights, monomer compositions, linkage patterns, and three-dimensional structures. Having undergone stringent Phase IV clinical trials, it also holds the distinction of being eligible for National Health Insurance coverage.



Functional Supplement


'Oral' Crystalline Micro-Particles


Not just limited to wall-breaking extraction, PhytoHealth utilizes rAPS® technology as its foundation, applying patented transformations to further develop the rAPP® food processing method. This process fully preserves the polysaccharide activity of the main root while significantly enhancing purity by removing impurities.

The rAPP® technology enhances oral absorption efficiency. Additionally, the patented crystalline 'micro-particle structure' improves the solubility and absorption of the polysaccharide. This enables rapid oral absorption and has been confirmed through tests for functionality, safety, and stability.                                                      

Functional Supplement

'Oral' Crystalline Micro-Particles

Not just limited to wall-breaking extraction, PhytoHealth utilizes rAPS® technology as its foundation, applying patented transformations to further develop the rAPP® food processing method. This process fully preserves the polysaccharide activity of the main root while significantly enhancing purity by removing impurities.

The rAPP® technology enhances oral absorption efficiency. Additionally, the patented crystalline 'micro-particle structure' improves the solubility and absorption of the polysaccharide. This enables rapid oral absorption and has been confirmed through tests for functionality, safety, and stability.





PhytoHealth, with the endorsement of Taiwan's FDA, employs its unique technology to develop functional food ingredients. We're committed to infusing the health benefits of these ingredients into everyday foods, thereby sharing our groundbreaking research with a broader audience. Whether it's our oral functional supplements or botanical medicine injections, we consistently source from the high-quality Astragalus membranaceus (Fisch.) Bge. PA1057. Additionally, we leverage shared core technology patents, ensuring we address the typical challenges of purity, activity, and absorption often found in standard Astragalus extracts.

rAPP® Core Refinement Tech ( refined Astragalus PolySaccharides Powder ) focuses on refining Astragalus Polysaccharides Powder. By blending it with patents for absorption efficiency and stability, and using precision tools, we've developed patented crystalline 'micro-particle structures'. These innovations elevate the water solubility and oral uptake of polysaccharides, allowing us to broaden the application of Astragalus polysaccharide injections to include oral formulations.


  Polysaccharide Absorption Patent

— German Patent, Nr.20 2020 101 993
— Japan Patent, No.322851
— Taiwan Patent, TW M597140 U

  Polysaccharide Absorption Patent

  German Patent, Nr.202020101993
  Japan Patent, No.322851
  Taiwan Patent, TW M597140 U

  High-Activity Stability Patent

— German Patent, Nr. 20 2020 101 994
— Japan Patent, No. 3226987
— Taiwan Patent, No. M597268 U

  High-Activity Stability Patent

  German Patent, Nr. 202020101994
  Japan Patent, No. 3226987
  Taiwan Patent, No. M597268 U

Throughout the entire production process, we maintain precise temperature control to safeguard the active structure and optimal molecular weight, guarding against degradation from excessive heat. Post-purification and concentration, increased concentration amplifies activity. We prioritize preserving this activity, guaranteeing lasting stability and sustained functionality.

Energetic and Vibrant Living


At PhytoHealth, we've revolutionized plant-based pharmaceutical front-end technology for oral formulations. This provides a convenient solution for daily intake and is tailored for prolonged well-being.

Animal studies highlight a twofold increase in vitality after just 14 days of consumption. This supports recovery, health maintenance, and regular daily activities, effectively combating feelings of fatigue and weakness.